Release date: 2017-12-25 The analysis of circulating tumor cells (CTCs / DTCs) at the molecular level has great potential clinical value. This method can be used to continuously evaluate prognosis and treatment effects in near real-time through minimally invasive techniques. However, there is currently no mature method for accurate molecular identification and analysis of these rare cells. IOPscience recently published two articles by researchers at the University of Southern California, which elaborated on a new approach to combining image analysis and signal normalization for CTCs/DTCs analysis. The method further integrates tissue mass spectrometry imaging (IMC) and metal-labeled antibodies based on an early established high-resolution single-cell analysis (HD-SCA) liquid biopsy method, thereby expanding the detectable range of circulating tumor cell characteristics. . In this article (Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry), the authors analyzed samples of patients with malignant prostate cancer by this method. The results show that IMC can extend the characterization of CTC to Detection includes a range of dozens of protein biomarkers, while phenotypic analysis of thousands of white blood cells. The authors point out that with this new approach, it is possible to understand a range of important biological properties that influence treatment outcomes, tumor metastasis, and immune surveillance, providing a wealth of valuable data for clinical diagnosis. In another article (Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis), the author elaborates the workflow of the method and uses HD-SCA method for PTTP (prostate tissue touch). Preparation) Samples such as prostate, bone marrow biopsy samples, and morphological proteomics and morphogenomic analysis of single cells in liquid samples such as peripheral blood and bone marrow extracts, such as nuclear features, protein expression, and morphology, detailed Heterogeneous features associated with prostate cancer are described. The authors note that this new single-cell assay reveals the origins of multiple clonal subtypes in patients with multiple metastatic disease who have just been diagnosed and untreated, demonstrating the use of prostate and bone marrow biopsy samples for real-time molecular analysis. The feasibility of the assessment and the possibility of elucidating the origin and evolution of cell metastasis in malignant tumors further affect clinical treatment. Reference: 1. Gerdtsson E., et al. Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry. 2017 2. Malihi. PD., et al. Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis. 2017 Source: Bio Valley Black Garlic Extract/Concentrate/Juice
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